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KMID : 0358420090520111117
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Korean Journal of Obstetrics and Gynecology
2009 Volume.52 No. 11 p.1117 ~ p.1126
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Effect of vitamin C and E on the lipid peroxide, antioxidant ability, and antioxidant vitamin levels in maternal and umbilical venous plasma
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Kim Yoon-Ha
Kim Jong-Woon
Kim Cheol-Hong
Cho Moon-Kyoung
Kim Seok-Mo
Kang Woo-Dae
Cho Hye-Yon
Yang Sung-Yeul
Ahn Bong-Whan
Song Tae-Bok
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Abstract
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Objective: This controlled trial investigated the effect of supplementation with vitamins C and E on the lipid peroxide, antioxidant ability, and antioxidant vitamin levels in full term maternal and umbilical venous plasma.
Methods: Forty pregnant women were randomized in this study. They were nulliparous or multiparous women with history of preeclampsia or preterm premature rupture of membranes (PPROM). Twenty women were given vitamin C (1,000 mg/day) and vitamin E (400 IU/day) from 15~20 gestational weeks to delivery. The others were not given, as a control group. Maternal venous blood was obtained before vitamin supplementation and just before delivery. Umbilical venous blood was obtained after delivery. Lipid peroxide level and oxygen-radical absorbance capacity (ORAC) were measured by thiobarbituric acid reaction and Cao’s method, respectively. Ascorbic acid, uric acid, β-carotene, retinol, α-tocopherol, and γ-tocopherol were measured by high performance liquid chromatography.
Results: Supplementation with vitamins C and E was associated with decrease in lipid peroxide levels and increase in ORAC values and α-tocopherol levels in maternal venous plasma. And it was also associated with decrease in lipid peroxide levels and increase in ORAC values and α-tocopherol levels in umbilical venous plasma.
Conclusion: Supplementation with vitamins C and E may be beneficial in the prevention of oxidant-antioxidant imbalance origin diseases such as preeclampsia, PPROM. And it also may affect antioxidant ability of the fetus.
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KEYWORD
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Vitamin supplementation, Total antioxidant ability, Maternal venous plasma, Umbilical venous plasma, Lipid peroxide
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